Where's The Fun? Detox

Active Ingredients

Amla (Emblica Officinale)

Shighru (moringa olifera)

Guduchi (Tinospora Cordifolia)

Haridra (curcuma longa)

Sunthi (zingiber officinale)

Bhringaraj (eclipta Alba)

Kalmegh (Andrographis paniculata)

Description:

An ideal solution for hangovers after a night of binge drinking. Reduces after effects of alcohol on body like drowsiness, fatigue, nausea, body ache and headaches.Reduces gastritis and burning sensation in stomach. Provides quick and effective relief after a hard night of drinking Reduces after effects of alcohol on body by rapidly eliminating acetaldehyde from blood and

protects the liver from additional damage caused by alcohol consumption. Elimination happens by increasing ADH (alcohol dehydrogenase) and ALDH (aldehyde dehydrogenase) activity in the body The close relation between ethanol and liver damage is mainly due to the fact that 80% of ingested alcohol is metabolized in the liver. Help your body reduce effects of alcohol on not

just your mood but also help protect your liver.

Ingredient description and their Hepatoprotective properties :

Amla (Emblica Officinale)

Scientific studies have shown amla to be effective in preventing/ameliorating the toxic effects of hepatotoxic agents like ethanol. Additionally, the phytochemicals quercetin, gallic acid, corilagin and ellagic acid are also reported to protect against the cytotoxic effects of paracetamol, microcystins, galactosamine and lipopolysaccharide. The hepatoprotective actions of amla appear to be mediated by its free radical scavenging, antioxidant, anti-inflammatory and modulation of the xenobiotic detoxification process and lipid metabolism. data indicate that the tannoid, flavonoid and NO scavenging compounds present in EFE may offer protection against free radical mediated oxidative stress in rat hepatocytes of animals with alcohol-induced liver injury.

Hepatoprotective properties

The hepatoprotective actions of amla appear to be mediated by its free radical scavenging, antioxidant, anti-inflammatory and modulation of the xenobiotic detoxification process and lipid metabolism. Hepatoprotective properties⁽¹⁶⁾

RESEARCH:

1. Amla has been proven to offer protection against a wide variety of hepatotoxic agents(substance which cause liver damage), such as ethanol, paracetamol, carbon tetrachloride, antitubercular drugs. Regular intake of amla has been shown to be

benefical in mitigating hyperlipidemia, metabolic syndrome, hepatic cellular carcinoma and hepatotoxicity resulting from iron overload. The main photochemical constituents quercetin, gallic acid, corilagin and ellagic acid were also observed to be

hepatoprotective against the toxicity of paracetamol, microcystins, galactosamine and lipopolysaccharide. By virtue of its antioxidant, anti-inflammatory and hypolipidemic actions and by modulation of detoxifying enzymes, it is safe to suggest that amla merits clinical studies, especially in the high risk group.⁽¹⁾

2. Fruit extract has radical scavenging activity and inhibit the lipid and protein oxidation in alcohol toxicity⁽²⁾

3. Extracts of Emblica officinalis were found to be potent antioxidants in vitro. Lipid peroxidative processes and related aldehydic end products could be involved in mediating chronic poisoning and thus be able to affect biological phenomena during the

development of chronic liver damage leading to fibrosis and eventually cirrhosis. Acute and chronic CCl4 administration increased lipid peroxide levels in serum and liver tissue. It has been reported that lipid peroxidation could stimulate collagen synthesis by

fibroblasts and hence the hydroxyproline levels. Pathological analysis supports the hepatoprotective activity of Emblica officinalis⁽³⁾

Shighru (Moringa olifera)

Moringa reduced liver damage as well as symptoms of liver fibrosis. Moringa extract decreases the CCl(4)-induced elevation of serum aminotransferase activities and globulin level, reducing liver damage and faster recovery. Biochemical parameters and histopathology results provide evidence that Moringa oleifera ethanolic extract has a great potential to prevent and improve liver damage due to its protective activity.

Hepatoprotective properties

RESEARCH:

1. In the present study, hepatotoxicity and oxidative stress mediated by alcohol abuse are exhibited by a significant increase in the activities of antioxidant enzymes, superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx) and the liver content of liver Malondialdehyde (MDA), and a significant decrease of reduced glutathione (GSH).

Strikingly, post-administration of Wistar rats with leaf extract of Moringa oleifera remarkably modulated the oxidative stress caused by alcohol administration. This is potentials of Moringa oleifera had been demonstrated in our earlier study . Our results showed that administration of ethanol significantly (P<0.001) increased the serum intracellular enzymes namely alanine aminotransferase (AST), alkaline phosphatase (ALP), aspartate aminotransferase (ALT) and GammaGlutamyl transpeptidase (GGT), indicating severe hepato-toxicity (Saravanan et al., 2006). However, administration of Moringa oleifera decreases significantly these enzyme levels. The reversal of elevated serum intracellular enzyme levels by Moringa oleifera extract after ethanol administration may be attributed to the stabilizing ability of the cell membrane preventing enzymes leakages as earlier postulated by Pari and Karthikesan (2007).⁽⁴⁾

2. Results showed a significant decrease in liver enzymes, TNF-α, and TGF-β in the treated and prophylactic groups compared to the acetaminophen group, and our biochemical data were consistent with the histopathological findings confirming the hepatoprotective effect of Moringa oleifera extract.⁽⁵⁾

Guduchi (Tinospora Cordifolia)

Heavy alcohol intake depletes the plasma vitamins due to hepatotoxicity and decreased intestinal absorption. Guduchi effectively increases the intestinal absorption and retaining power of liver that regulated alcohol-induced multivitamin deficiency.

Hepatoprotective properties

RESEARCH:

1. Overall data depict that moderate alcohol intake is also hepatotoxic and decreases intestinal absorption. However, Tinospora Cordifolia treatment effectively increased the intestinal absorption and retaining power of liver that regulated alcohol-induced multivitamin deficiency⁽⁶⁾

2. It was concluded that Tinospora cordifolia indeed has a high potential in healing liver parenchyma and regeneration of liver cells. Thus it may act even in humans as potent liver tonic, thus has equivalent therapeutic value⁽⁷⁾

Haridra (curcuma longa)

Curcumin attenuates alcohol-induced liver injury via improving mitochondrial function and attenuating endoplasmic reticulum stress and inflammation. Turmeric thus has the beneficial effects on liver.

Hepatoprotective properties

RESEARCH:

1. Side effects of alcohol abuse on hepatocellular denegation and cirrhosis, it has been shown that alcohol abuse can cause mitochondrial dysfunction in hepatocytes and also cause induction of lipid peroxidation and glutathione circulatory disorders as well as antioxidant enzymes. Alcohol-induced mitochondrial dysfunction in hepatocytes may

also initiate inflammation and increase the production of pro-inflammatory biomarkers that lead to hepatocyte cell dysfunction. According to current literature, alcohol-induced liver cell cirrhosis has been mediated by apoptosis in both intrinsic and extrinsic pathways. According to the various advantages of curcumin results from the current

literature review, curcumin may act as a potent hepato-protective agent in liver dysfunction in alcohol abuse subjects. Based on reported literature, curcumin has been shown to inhibit alcohol-induced mitochondrial dysfunction, lipid peroxidation, antioxidant enzymes, and glutathione ring defect. Literature indicates that curcumin may inhibit inflammation in hepatic alcohol abuser cells. According to the results of studies reviewed in the current literature, curcumin may inhibit alcohol induced mitochondrial dysfunction and thus prevent the occurrence of apoptosis. On the other hand, curcumin inhibition of a cell death signaling pathway that activates by alcohol in hepatocellular tissue may inhibit the occurrence of an extrinsic pathway of apoptosis. Taken together, according to the type of literature, curcumin treatment of alcohol abusers in both human and animal subjects may reduce alcohol-induced hepatocellular apoptosis, oxidative stress and inflammation, and may act as a hepato-protective agent against alcoholinduced hepatotoxicity⁽⁸⁾

2. The present study, coupled with our previous report, demonstrates that curcumin attenuates chronic alcohol-induced liver damage probably through multiple targets, among which antioxidative stress, mitochondrial damage repair, inhibition of endoplasmic reticulum stress, and inflammation are involved. Therefore, curcumin as a potential natural anti-ALD (Alcoholic liver disease) drug is worthy of more preclinical and clinical studies.⁽⁹⁾

Sunthi (zingiber officinale)

Ginger is best known as a calming remedy for indigestion, nausea, and upset stomach, it is also used to relieve headaches and migraine. The chemical compounds in ginger include gingerols and shogaols have proven anti-inflammatory and pain-relieving effects. These compounds are also effective at treating nausea and vomiting, two symptoms associated with migraine attacks. The best available evidence demonstrates that ginger is an effective and inexpensive treatment for nausea and vomiting and is safe.

Hepatoprotective properties

Ginger (Zingiber officinale) has been used as an important ingredient in cooking and traditional herbal medicine for a long time. It exhibits antioxidant potential and hepatoprotective activity. 6-Gingerol as the major bioactive constituent of ginger could efficiently scavenge various free radicals . The antioxidant compounds of ginger may modulate the oxidative stress induced by alcohol. SOD, ascorbic acid, and glutathione peroxidase (GSH) levels were decreased, and glutathione S-transferase (GST) activity was increased in alcohol treated rats. However, after treatment with the extract of ginger, these parameters came to normal.⁽¹²⁾

RESEARCH:

1. It can be concluded that ginger extract has protective effects against toxicity induced by ethanol in the liver of male rats. The protective effect may be attributed to the presence of phenolics and flavonoids components.⁽¹⁰⁾

2. In the present study, the hepatoprotective activity of ethanolic extract of rhizomes of Z. officinale (ERZO) was explored in vitro and in vivo. Histology, ERZO slowed down liver fibrosis progression and prevents the generation of free radical induced by Thioacetamide (TAA), which provide an insight into the mechanism of its biological action. According to these data, Z. officinale ingestion is safe in humans and might be apromising hepatoprotective agent.⁽¹¹⁾

3. Excessive alcohol consumption caused alcoholic fatty liver disease (AFLD). The ginger essential oil and citral exhibited hepatoprotective activity against AFLD in mice. The amounts of metabolites in serum such as d-glucurono-6,3-lactone, glycerol-3-phosphate, pyruvic acid, lithocholic acid, 2-pyrocatechuic acid, and prostaglandin El increased after alcohol administration, but the levels were recovered in treatment groups . Therefore, ginger could be used as a candidate to the prevention and treatment of hangover and organ damages induced by overconsumption of alcohol through its antioxidant action.⁽¹²⁾

Hepatoprotective properties

RESEARCH:

1. The Ayurvedic Pharmacopoeia of India considers the plant as hepatoprotective.⁽¹³⁾

2. The present study reveals that Eclipta alba has a protective role against liver diseases such as liver cirrhosis and infective hepatitis .The componants of (wedelolactone, demethylwedelolactone and saponins) reduce fat deposition, mononuclear infiltration necrotic foci and stimulated regeneration hepatocytes in the liver.⁽¹⁴⁾

3. Antihyperlipidemic and hepatoprotective properties of E. alba were done using Albino mice caused by fatty foods [24] . Treatment of hypercholesterolemic mice with E. alba displayed a significant reduction in serum LDL (low-density lipoprotein) and very LDL cholesterol compared to hypercholesterolemic mice. High-fat diets have elevated levels

of SGOT, SGPT, and ALP, while the same markers were significantly enhanced by the E. alba compared to the standard group.⁽¹⁵⁾

Kalmegh (Andrographis paniculata)

Andrographolide is the active component in Andrographis which is the best liver protective herb in the world. Several studies have shown its hepatoprotective activity. It helps balance liver enzymes, improving liver functionality and inhibits hypatocyte proliferation.

Hepatoprotective properties

RESEARCH:

1. The present study shows the hepatoprotective activity of the crude methanolic extracts of the Andrographis paniculata. This is concluded using the results obtained from the histological studies as well as the liver protein content.⁽¹⁷⁾

2. In the present study the folklore medicinal plant Andrographis paniculata (Family:Acanthaceae) have been selected for hepatoprotective study in ethanol induced liver toxicity in male albino rats.⁽¹⁸⁾

3. The present study clearly indicates that the antioxidant effect elucidated by aqueous extract of Andrographis panicu/ata is possibl y due to their ability to activate antioxidant enzymes that catalyse the reaction of oxidants and their use for severe liver damage condition.⁽¹⁹⁾

REFERENCES:

REFERENCES:

1. https://pubmed.ncbi.nlm.nih.gov/23978895/#:~:text=The%20hepatoprotective%20actions%20o

f%20amla,detoxification%20process%20and%20lipid%20metabolism.

2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994578/pdf/12291_2010_Article_58.pdf

3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994578/

4. https://scihub.org/AJBMS/PDF/2012/1/AJBMS-2-1-6-14.pdf

5. https://jmhg.springeropen.com/articles/10.1186/s43042-020-00106-z

6. https://watermark.silverchair.com/agv130.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3

ZL_9Cf3qfKAc485ysgAAA1EwggNNBgkqhkiG9w0BBwagggMMIIDOgIBADCCAzMGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMnAvRLhPmoaZjKFGDAgEQg

IIDBNUrfWWi9NeWXVfQH6RUKqlBDVjQpdd0U7Yyv2BavHofdAflA

7. https://rjptonline.org/HTMLPaper.aspx?Journal=Research%20Journal%20of%20Pharmacy%20a